By Tracy Beanz & Michelle Edwards
Melatonin—a hormone essential for regulating the body’s circadian rhythm, or internal 24-hour clock—is crucial for healthy sleep-wake cycles and seasonal biological changes. Produced by the brain in response to darkness, it largely impacts sleep patterns by signaling when it’s time to rest. Melatonin is produced by the pineal gland in the brains of vertebrates and invertebrates, with levels rising at night to promote sleepiness while lowering during daylight hours. Since nature is simply amazing, it is no shock that melatonin is also found in plants, bacteria, and algae. Exposure to light at night can block melatonin production, leading to myriad potential adverse health consequences for all. Moreover, in humans, melatonin aids in disease management through its antioxidant, anti-inflammatory, neuroprotective, and immune-modulating properties. Without question, melatonin, identified by scientists over 60 years ago, is connected to sound health.
The pineal gland is not the only place melatonin, often called the “hormone of darkness,” is synthesized. It is also synthesized to a lesser degree in the retina, gastrointestinal tract, liver, kidneys, and other organs. In the retina, melatonin modulates photoreceptor activity and protects against oxidative damage. In the gastrointestinal tract, it regulates gut microbiota and intestinal health. The presence of melatonin in bodily fluids like bile, cerebrospinal fluid, and saliva suggests its widespread physiological importance. Yet, insignificant emphasis is put on its role in human health.
Melatonin synthesis begins with the conversion of tryptophan to serotonin, which is then acetylated and methylated to produce melatonin. This process is influenced by norepinephrine, folate, and vitamin B6. Again, light exposure suppresses melatonin production, while darkness promotes its synthesis. The suprachiasmatic nucleus (SCN) of the brain plays a crucial role in melatonin release, regulating sleep-wake cycles. Once produced, melatonin is secreted into the bloodstream and cerebrospinal fluid, which is the fluid around the brain and spinal cord and conveys signals to distant organs.
Melatonin, undoubtedly an amazing and vital hormone, is amphiphilic in nature, meaning it possesses both hydrophilic (water-attracting) and hydrophobic (water-repelling) properties. Thus, melatonin crosses cellular barriers, acting upon mitochondria and other organelles. It is also a potent antioxidant, counteracting oxidative stress by scavenging reactive oxygen and nitrogen species. In addition to sleep regulation, melatonin influences immune response and metabolism and has therapeutic potential for neurodegenerative diseases, psychiatric disorders, and even cancer. A 31-page article in Springer Nature, published on January 11, 2024, underscored the significance of melatonin, concluding:
“Melatonin is a ubiquitous molecule in almost all taxa, including bacteria, algae, fungi, plants, and animals. Melatonin is considered to regulate the development and function of immune cells due to its many properties in various organs and tissues.
It plays a crucial role in combating cancer and in many neurological disorders. Melatonin exhibits the intrinsic property of free radical scavenging ability to exert its antioxidant property.
Additionally, melatonin’s immunomodulating property makes it an excellent anti-inflammatory agent. The low level of circulating melatonin could directly initiate neurodegeneration and also aids in the progression of sleep disorders.
Therapeutic application of melatonin for the prevention and treatment of many disorders can be implemented after determining the correct dosage based on the preclinical studies.”
Let’s read that again: melatonin—produced by the rarely-acknowledged and impaired pineal gland—plays a crucial role in combating cancer and in many neurological disorders. Indeed, the article explains the long list of melatonin’s healing qualities. For one, it acts as a direct scavenger of free radicals and enhances the activity of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx). It stabilizes mitochondrial membranes, preventing oxidative stress-related cellular damage. Its metabolites, including AFMK and AMK, further enhance its antioxidative properties. Melatonin also modulates inflammation (the body’s natural response to injury or infection, which can also lead to disease if it becomes chronic), by regulating cytokine levels.
In cancer therapy, the article explains that melatonin exhibits oncostatic properties, meaning it helps inhibit cancer cell proliferation, metastasis, and angiogenesis. It not only suppresses tumor growth but also enhances the effectiveness of chemotherapeutic agents while minimizing their side effects. Research suggests melatonin has therapeutic potential in various cancers, including breast, lung, liver, prostate, and ovarian cancers.
Besides combating cancer, the study highlights how melatonin plays a vital role in neuroprotection, offering therapeutic benefits for neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. It helps reduce the accumulation of amyloid-beta plaques, which are characteristic of Alzheimer’s and protects dopaminergic neurons in Parkinson’s, potentially slowing disease progression. Likewise, melatonin supports stroke recovery by decreasing infarction volume and inflammation, promoting better outcomes for patients recovering from ischemic strokes.
It doesn’t stop there. Melatonin contributes to cardiovascular health by regulating blood pressure, reducing oxidative stress-induced myocardial damage, and preventing arrhythmias. It also plays a role in protecting the heart from ischemic injuries and improving overall cardiac function following myocardial infarction. Beyond cardiovascular health, melatonin influences metabolism and endocrine functions. It regulates body weight, insulin sensitivity, and lipid metabolism, which helps prevent obesity. This is achieved, in part, through its interaction with the all-important gut microbiota, which influences energy balance and metabolic health.
As an immune system modulator, the study notes that melatonin enhances immune function by boosting immune cell production and balancing cytokine release, helping to control chronic inflammation. It has been linked to reducing the severity of autoimmune diseases and viral infections by supporting both innate and adaptive immune responses, improving the body’s defense mechanisms. Likewise, as previously mentioned, melatonin plays a crucial role in sleep regulation and mood stabilization. It helps regulate serotonin pathways, making it effective in managing depression, anxiety, and seasonal affective disorder (SAD). Further, it improves sleep quality, particularly for individuals experiencing insomnia, jet lag, and shift work-related sleep disturbances, ultimately contributing to overall well-being.
Realizing the numerous ways melatonin—again, produced by the wonderful pineal gland—can positively influence health, coupled with the countless ways the global elite have repeatedly sought to calcify our pineal glands, it’s time to wake up. Pineal gland calcification is influenced by several pharmaceuticals (like SSRIs, statins, aluminum-based medications including antacids, and vaccines), many substances (like fluoride, heavy metals in foods, cookware, vaccines, and dental fillings, as well as processed foods, artificial sweeteners, refined sugar, pesticides like glyphosate, and so on) and environmental factors (like EMFs, Wi-Fi, cell phones, and blue light from ever-present screens), which can negatively impact melatonin production and, thus, disrupt circadian rhythms.
Undoubtedly, the accumulation of calcium deposits in the pineal gland may damage its ability to function optimally, leading to numerous health concerns, including a disruption in melatonin production. Take charge and do research. Reducing exposure to these contributing factors—each pushed by Big Pharma, the deep state, and those profiting off of persistent illness— and supporting pineal gland health through proper detoxification, a healthy diet of local organic foods, sunlight exposure, and restricting exposure to environmental toxins can help preserve its function and therefore improve melatonin production for better sleep and overall well-being.
